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United States PatentRE39679
Robichaud , ; et al.June 5, 2007
Title
Substituted heterocycle fused gamma-carbolines
Abstract
The present invention is directed to certain novel compounds represented by structural Formula (I) ##STR00001## or pharmaceutically acceptable salt forms thereof, wherein R.sup.1, R.sup.5, R.sup.6a, R.sup.6b, R.sup.7, R.sup.8, R.sup.9, X, b, k, m, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
Inventors:Robichaud; Albert J. (Landenberg, PA), Lee; Taekyu  (Wilmington, DE), Deng; Wei  (Wilmington, DE), Mitchell; Ian S.  (Philadelphia, PA), Yang; Michael Guang  (Wilmington, DE), Haydar; Simon  (Niskayuna, NY), Chen; Wenting  (Exton, PA), McClung; Christopher D.  (Wilmington, DE), Calvello; Emile J. B.  (Bryn Mawr, PA), Zawrotny; David M.  (Moorestown, NJ), Rajagopalan; Parthasarathl  (Chennai, IN)
Assignee:Bristol-Myers Squibb Pharma Company (Princeton, NJ)
Appl. No.:11/356,423
Filed:February 16, 2006
PCT Pub Date:June 5, 2007
Current U.S. Class:514/211.1 514/215 514/224.5 514/287 540/468 540/546 544/14 544/99 
Current International Class:C07D 267/22 (20060101) C07D 265/34 (20060101) C07D 267/02 (20060101) C07D 279/00 (20060101) C07D 281/18 (20060101)
Field of Search:514/211.1,215,224.5,287 540/468,546 544/14,99
U.S. Patent Documents
3299078January 1967Pachter
3914421October 1975Rajogopalan
4013652March 1977Rajagopalan
4088647May 1978Glushkov et al.
4115577September 1978Rajagopalan
4183936January 1980Rajagopalan
4219550August 1980Rajagopalan
4238607December 1980Rajagopalan
4997831March 1991Bays et al.
5100884March 1992Hamminga et al.
5223625June 1993Van Wijngaarden et al.
5328905July 1994Hamminga et al.
5512575April 1996Jacobs et al.
5654139August 1997Lappalainen et al.
5902815May 1999Olney et al.
5908830June 1999Smith et al.
6107324August 2000Behan et al.
6140509October 2000Behan et al.
6407092June 2002Hester et al.
Foreign Patent Documents
0725068Aug., 1996EP
2011107Aug., 1991CA
2213283Feb., 1974FR
WO 0064899Nov., 2000WO
Other References
Database Caplus 'Online! Chemical Abstracts Service; 84:59411, XP002153997 RN = 58121-96-3, 58121-97-4 & Khim. Geterotsikl. Soedin., No. 9, 1975, pp. 1262-1266, & Chemical Abstracts, vol. 84, No. 9, Mar. 1, 1976 Columbus, Ohio US; abstract No. 59411, Orlova et al.: "Synthesis of 2,3,4,5-tetrahydro-1,5-benzox(and thi)azepines and their use for synthesis of condensed indoles". cited by other .
Bickerdike MJ, Vickers, SP, Dourish CT, (1999) S-HT2C receptor modulation and the treatment of obesity. Diabetes, Obesity and Metabolism 1:207-214. cited by other .
Tecott LH, et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature (London) 374:542-546. cited by other .
Cryan JF, Lucki I, (2000) Antidepressant-like behavioral effects mediated by 5-hydroxtryptamine2C receptors. J. Pharmacol. Exper. Ther. 295:1120-1126. cited by other .
Millan MJ, Peglion JL, Lavielle G, Perrin-Monneyron S, (1997) 5-HT2C receptors mediate penile erection in rats: actions of novel and selective agonists and antagonists. Eur. J. Pharmacol. 325:9-12. cited by other .
Martin JR, et al. (1998) 5-HT2C receptor agonists: Pharmacological characteristics and therapeutic potential. J. Pharmacol. Exper. Ther. 286:913-924. cited by other .
Meltzer HY. (1999) The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 21 (2) :106S115S. cited by other .
Curzon et al, Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability, TiPS, vol. 18, 1997; 21-25. cited by other .
Mora et al, Role of 5-HT2A and 5-HT2C Receptor subtypes in the Two Types of Fear Generated by the Elevated T-Maze. Pharma. Biolchem. & Behavior, vol. 58, No. 4, 1997; 1051-1057. cited by other .
Jenck et al, Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats, European Neuropsychopharmacology, 8, 1998; 161-168. cited by other .
Leysen, Selective 5-HT2c agonists as potential antidepressants. Drugs, 1999, 2(2); 109-120. cited by other .
Jenck et al, The role of 5-HT2c receptors in affective disorders. Exp. Opin. Invest. Drugs, 1998, 7(10); 1587-1599. cited by other .
Kennett, 5-HT drugs and eating disorders, I Drugs, 1998, vol. 1, No. 4; 456-470. cited by other .
Brewerton, Induction of migrainelike headaches by the serotonin agonist m-chlorophenylpiperazine, Clin. Pharmacol. Ther., 1988, 605-609. cited by other .
Kahn et al, m-Chlorophenylpiperazine as a probe of serotonin function, Biol. Psychiatry, 1991; 30: 1139-1166. cited by other .
Gibson et al, Evidence that mCPP-induced Anxiety in the Plus-maze is mediated by Postsynaptic 5-HT2c receptors but not by sympathomimetic effects, Neuropharmacology, vol. 33, No. 3, 4, 1994; 457-465. cited by other.~
Primary Examiner: Kifle; Bruck
Attorney, Agent or Firm:Duncan, Jr.; Sammy G.
Parent Case Text


This application claims the benefit of U.S. Provisional Application No. 60/139,321, filed Jun. 15, 1999.
Claims

What is claimed is:
1. A compound of formula (I): ##STR00046## or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein: b is a single bond; X is --O--, --S--, --S(.dbd.O)--, or --S(.dbd.O).sub.2--; R.sup.1 is selected from H, C(.dbd.O)R.sup.2, C(.dbd.O)OR.sup.2, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-7 cycloalkyl, C.sub.1-6 alkyl substituted with 0-2 R.sup.2, C.sub.2-6 alkenyl substituted with 0-2
R.sup.2, aryl substituted with 0-2 R.sup.2, and 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R.sup.2; R.sup.2, at each occurrence, is independently selected from F, Cl, CH.sub.2F, CHF.sub.2, CF.sub.3, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloakyl, phenyl substituted with 0-5 R.sup.42; C.sub.3-10 carbocyclic group substituted with 0-3
R.sup.41, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.42; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is selected from H; H, --OH, --NR.sup.46R.sup.47, --CF.sub.3, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.3-4 haloalkyl, and aryl substituted with O-3 R.sup.44; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-8 alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 0-2
R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3
R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O) NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14) NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.8 is selected from --OH, --CN, --NO.sub.2, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 1-2 R.sup.33, C.sub.2-4 alkenyl substituted with 0-2 R.sup.13, C.sub.2-4 alkynyl substituted with 0-1 R.sup.11, C.sub.3-10 carbocyclic group substituted wit 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O) NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14) NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from --CN, --NO.sub.2, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-8 alkoxy, C.sub.3-10 cycloalkyl, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10
membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O) NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14) NR.sup.12R.sup.13, S(O)R.sup.12, S(O)NR.sup.12R.sup.13, SO(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl substituted with 0-1 R.sup.12a, C.sub.2-4
alkenyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkynyl substituted with 0-1 R.sup.12a, C.sub.3-6 cycloalkyl substituted with 0-3 R.sup.33, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10
membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12a, at each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R12 and R13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R14)--; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-3 R.sup.16; R.sup.14, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; R.sup.15, at each occurrence, is independently selected from H, C.sub.1-4
alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; R.sup.16, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-3 haloalkyl-oxy-, and C.sub.1-3 alkyloxy; R.sup.32, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, and C.sub.1-4 alkyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-6 alkyl, C.sub.2-4 alkenyl, C.sub.2-6 alkynyl, C.sub.2-6 cycloalkyl, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkyl-oxy-, C.sub.1-4
alkyloxy, C.sub.1-4 alkylthio-, C.sub.1-4 alkyl-C(.dbd.)--, C.sub.1-4 alkyl-C(.dbd.O)NH--, C.sub.1-4 alkyl-OC(.dbd.)--, C.sub.1-4 alkyl-C(.dbd.O)O--, C.sub.3-6 cycloalkyl-oxy-, C.sub.3-6 cycloalkylmethyl-oxy-; C.sub.1-4 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and C.sub.2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47 , NO.sub.2, CN; C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl C.sub.1-4 alkyl substituted with 0-1 R.sup.43; aryl substituted with 0-3 R.sup.42, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6 cycloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43; aryl substituted with 0-3 R.sup.44, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.43 is C.sub.2-6 cycloalkyl or aryl substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, C.sub.1-4 alkyl, and C.sub.1-4 alkoxy; R.sup.45 is C.sub.1-4 alkyl; R.sup.46, at each occurrence, is independently selected from H and C.sub.1-4
alkyl; R.sup.47, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; k is 1 or 2; m is 0, 1, or 2; and n is 1, 2, or 3; provided when m is 0 or 1 then k is 1 or 2; provided when m is 2 then k is 1.
2. A compound of claim 1 wherein: X is --O-- or --S--; R.sup.1 is selected from H, C(.dbd.O)R.sup.2, C(.dbd.O)OR.sup.2, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.1-4 alkyl substituted with 0-2 R.sup.2, C.sub.2-4 alkenyl substituted with 0-2 R.sup.2, and C.sub.2-4 alkynyl substituted with 0-2 R.sup.2; R.sup.2, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloakyl, phenyl substituted with 0-5 R.sup.42; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.41, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is selected independently from H, --OH, --NR.sup.46R.sup.47, --CF.sub.3, C.sub.1-3 alkyl, and C.sub.1-3 alkoxy; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkyl, C.sub.1-6 alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2
R.sup.33, C.sub.1-4 alkyl substituted with 0-2 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O) NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14) NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12; R.sup.8 is selected from --OH, --CN, --NO.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 1-2 R.sup.11, C.sub.2-4 alkenyl substituted with 0-2 R.sup.11, C.sub.2-4 alkynyl substituted with 0-1 R.sup.11, C.sub.3-10
carbocyclic group substituted wit 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O) NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14) NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from --CN, --NO.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, C.sub.3-10 cycloalkyl, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O) NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14) NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, SO(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, and NR.sup.14S(O).sub.2R.sup.12; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl substituted with 0-1 R.sup.12a, C.sub.1-4 alkenyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkynyl substituted with 0-1 R.sup.12a, C.sub.3-6 cycloalkyl substituted with 0-3 R.sup.33, phenyl substituted with
0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12a, at each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-3 R.sup.16; R.sup.14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.15, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.31, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, and C.sub.1-4 alkyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.1-4
haloalkyl, C.sub.1-4 haloalkyl-oxy-, C.sub.1-4 alkyloxy-, C.sub.1-4 alkylthio-, C.sub.1-4 alkyl-C(.dbd.)--, C.sub.1-4 alkyl-C(.dbd.O)NH--, C.sub.1-4 alkyl-OC(.dbd.)--, C.sub.1-4 alkyl-C(.dbd.O)O--, C.sub.3-6 cycloalkyl-oxy-, C.sub.3-6
cycloalkylmethyl-oxy-; C.sub.1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and C.sub.2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47 , NO.sub.2, CN, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl C.sub.1-4 alkyl substituted with 0-1 R.sup.43, aryl substituted with 0-3 R.sup.42, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6 cycloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43; aryl substituted with 0-3
R.sup.44, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.43 is C.sub.3-6 cycloalkyl or aryl substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, C.sub.1-4 alkyl, and C.sub.1-4 alkoxy; R.sup.45 is C.sub.1-4 alkyl; R.sup.46, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; R.sup.47, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; k is 1 or 2; m is 0 or 1; and n is 1 or 2.
3. A compound of claim 1 wherein: X is --S--; R.sup.1 is selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-4 cycloalkyl, C.sub.1-3 alkyl substituted with 0-1 R.sup.2, C.sub.2-3 alkenyl substituted with 0-1
R.sup.2, and C.sub.2-3 alkynyl substituted with 0-1 R.sup.2; R.sup.2, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloakyl, phenyl substituted with 0-5 R.sup.42; C.sub.3-6
carbocyclic group substituted with 0-3 R.sup.41, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is H, methyl, ethyl, methoxy, --OH, or --CF.sub.3; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 0-2 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3
R.sup.33, aryl substituted with 0-5 R.sup.33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.8 is selected from --OH, --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 1-2 R.sup.11, C.sub.2-4 alkenyl substituted with 0-2 R.sup.11, C.sub.2-4 alkynyl substituted with 0-1
R.sup.11, C.sub.3-10 carbocyclic group substituted wit 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3
R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4
alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3, heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkenyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkynyl substituted with 0-1 R.sup.12a, C.sub.3-6 cycloalkyl substituted with 0-3 R.sup.33, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12a, at each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3
R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a
9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of one N, two N, three N, one N one O, and one N one S; wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-2 R.sup.16; R.sup.14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.15, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.31, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, methyl, ethyl, and propyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6
alkynyl, C.sub.3-6 cycloalkyl, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkyl-oxy-, C.sub.1-4 alkyloxy-, C.sub.1-4 alkylthio-, C.sub.1-4 alkyl-C(.dbd.)--, C.sub.1-4 alkyl-C(.dbd.O)NH--, C.sub.1-4 alkyl-OC(.dbd.)--, C.sub.1-4 alkyl-C(.dbd.O)O--, C.sub.3-6
cycloalkyl-oxy-, C.sub.3-6 cycloalkylmethyl-oxy-; C.sub.1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and C.sub.2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47 , NO.sub.2, CN, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, and C.sub.1-3 alkyl; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, C.sub.3-6 cycloalkyl, and C.sub.1-3 alkyl; R.sup.43 is cycloalkyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl; k is 1; m is 1; and n is 1 or 2.
4. A compound of claim 1 wherein: X is --S--; R.sup.1 is selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-4 cycloalkyl, C.sub.1-3 alkyl substituted with 0-1 R.sup.2, C.sub.2-3 alkenyl substituted with 0-1
R.sup.2, and C.sub.2-3 alkynyl substituted with 0-1 R.sup.2; R.sup.2, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, phenyl substituted with 0-5 R.sup.42; C.sub.3-6
carbocyclic group substituted with 0-3 R.sup.41, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is H, methyl, ethyl, methoxy, --OH, or --CF.sub.3; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, F, Cl, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --OCF.sub.3, --CN, and --NO.sub.2, R.sup.8 is selected from --OH, --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 1-2 R.sup.11, C.sub.2-4 alkenyl substituted with 0-2 R.sup.11, C.sub.2-4
alkynyl substituted with 0-1 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-6 membered heterocyclic ring system comprising 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4
alkynyl, C.sub.1-4 alkoxy, (C.sub.1-4 haloalkyl) oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O , and S substituted with 0-3 R.sup.31; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkenyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkynyl substituted with 0-1 R.sup.12a, C.sub.3-6 cycloalkyl substituted with 0-3 R.sup.33, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12a, at each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.33; C.sub.3-10
carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.33; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R.sup.16; R.sup.14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.15, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.31, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, methyl, ethyl, and propyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkyl-oxy-, C.sub.1-4 alkyloxy; C.sub.1-4 alkylthio-, C.sub.1-4 alkyl-C(.dbd.O)--, C.sub.1-4
alkyl-C(.dbd.O)NH--, C.sub.1-4 alkyl-OC(.dbd.O)--, C.sub.1-4 alkyl-C(.dbd.O)O--, C.sub.3-6 cycloalkyl-oxy-, C.sub.3-6 cycloalkylmethyl-oxy-; C.sub.1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; and C.sub.2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, and C.sub.1-3 alkyl; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, C.sub.3-6 cycloalkyl, and C.sub.1-3 alkyl; R.sup.43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl; k is 1; m is 1; and n is 1 or 2.
5. A compound of claim 1 wherein: X is --S--; R.sup.1 is selected from H, C.sub.1-5 alkyl substituted with 0-1 R.sup.2, C.sub.2-5 alkenyl substituted with 0-1 R.sup.2, and C.sub.2-3 alkynyl substituted with 0-1 R.sup.2; R.sup.2 is C.sub.3-6
cycloalkyl; R.sup.5 is H, methyl, ethyl, or propyl; R.sup.6a is H, methyl, or ethyl; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, F, Cl, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --OCF.sub.3, --CN, and --NO.sub.2, R.sup.8 is selected from methyl substituted with R.sup.11; ethenyl substituted with R.sup.11; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from phenyl-substituted with 0-5 fluoro; 2-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl substituted with R.sup.33; 2-(H.sub.3CC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(HC(.dbd.O))-phenyl-substituted with R.sup.32;
2-(H.sub.3CCH(OH))-phenyl-substituted with R.sup.32; 2-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2)-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33;
2-(H.sub.3COCH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3COCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH(OMe))-phenyl-substituted with R.sup.33; 2-(H.sub.3COC(.dbd.O))-phenyl-substituted with R.sup.33;
2-(HOCH-CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-((MeOC.dbd.O)CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-(methyl)-phenyl-substituted with R.sup.33; 2-(ethyl)-phenyl-substituted with R.sup.33; 2-(i-propyl)-phenyl-substituted with R.sup.33;
2-(F.sub.3C)-phenyl-substituted with R.sup.33; 2-(NC)-phenyl-substituted with R.sup.33; 2-(H.sub.3CO)-phenyl-substituted with R.sup.33; 2-(fluoro)-phenyl-substituted with R.sup.33; 2-(chloro)-phenyl-substituted with R.sup.33;
3-(NC)-phenyl-substituted with R.sup.33; 3-(H.sub.3CO)-phenyl-substituted with R.sup.33; 3-(fluoro)-phenyl-substituted with R.sup.33; 3-(chloro)-phenyl-substituted with R.sup.33; 4-(NC)-phenyl-substituted with R.sup.33; 4-(fluoro)-phenyl-substituted with R.sup.33; 4-(chloro)-phenyl-substituted with R.sup.32; 4-(H.sub.3CS)-phenyl-substituted with R.sup.33; 4-(H.sub.3CO)-phenyl-substituted with R.sup.33; 4-(ethoxy)-phenyl-substituted with R.sup.33; 4-(i-propoxy)-phenyl-substituted with R.sup.33;
4-(i-butoxy)-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 4-((H.sub.3).sub.2CHC(.dbd.O))-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33;
4-(H.sub.3CC(.dbd.O)-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 4-((H.sub.3C).sub.2CHCH(OH)-phenyl-substituted with R.sup.32; 4-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33;
4-(H.sub.3CCH(OH))-phenyl-substituted with R.sup.33; 4-(cyclopropyloxy)-phenyl-substituted with R.sup.33; 4-(cyclobutyloxy)-phenyl-substituted with R.sup.33; and 4-(cyclopentyloxy)-phenyl-substituted with R.sup.33; R.sup.12 is selected from phenyl-substituted with 0-5 fluoro; 2-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 2-(H.sub.3CC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(HC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH(OH))-phenyl substituted with R.sup.33; 2-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2)-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3COCH.sub.2)-phenyl-substituted with R.sup.33;
2-(H.sub.3COCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH(OMe))-phenyl-substituted with R.sup.33; 2-(H.sub.3COC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2CH.dbd.CH)-phenyl-substituted with R.sup.33;
2-((MeOC.dbd.O)CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-(methyl)-phenyl-substituted with R.sup.33; 2-(ethyl)-phenyl-substituted with R.sup.33; 2-(i-propyl)-phenyl-substituted with R.sup.33; 2-(F.sub.3C)-phenyl-substituted with R.sup.33;
2-(NC)-phenyl-substituted with R.sup.33; 2-(H.sub.3CO)-phenyl-substituted with R.sup.33; 2-(fluoro)-phenyl-substituted with R.sup.33; 2-(chloro)-phenyl-substituted with R.sup.33; 3-(NC)-phenyl-substituted with R.sup.33;
3-(H.sub.3CO)-phenyl-substituted with R.sup.33; 3-(fluoro)-phenyl-substituted with R.sup.33; 3-(chloro)-phenyl-substituted with R.sup.33; 4-(NC)-phenyl-substituted with R.sup.33; 4-(fluoro)-phenyl-substituted with R.sup.33;
4-(chloro)-phenyl-substituted with R.sup.33; 4-(H.sub.3CS)-phenyl-substituted with R.sup.33; 4-(H.sub.3CO)-phenyl-substituted with R.sup.33; 4-(ethoxy)-phenyl-substituted with R.sup.33; 4-(i-propoxy)-phenyl-substituted with R.sup.33;
4-(i-butoxy)-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 4-((H.sub.2C).sub.2CHC(.dbd.O) )-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33;
4-(H.sub.3CC(.dbd.))-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 4-((H.sub.3C).sub.2CHCH(OH))-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33;
4-(H.sub.3CCH(OH))-phenyl-substituted with R.sup.33; 4-(cyclopropyloxy)-phenyl-substituted with R.sup.33; 4-(cyclobutyloxy)-phenyl-substituted with R.sup.33; and 4-(cyclopentyloxy)-phenyl-substituted with R.sup.33; R.sup.13 is H, methyl, or ethyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring selected from pyrrolyl, pyrrolidinyl, imidazolyl, piperidinyl, piperizinyl, methylpiperizinyl, and morpholinyl; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing form 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R.sup.16; R.sup.15 is H, methyl, ethyl, propyl, or butyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.33, at each occurrence, is independently selected from H, F, Cl, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --OCF.sub.3, --CN, and --NO.sub.2; k is 1; m is 1; and n is 1 or 2.
6. A compound of claim 1 wherein: X is --O--; R.sup.1 is selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-4 cycloalkyl, C.sub.1-3 alkyl substituted with 0-1 R.sup.2, C.sub.2-3 alkenyl substituted with 0-1
R.sup.2, and C.sub.2-3 alkynyl substituted with 0-1 R.sup.2, R.sup.2, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, phenyl substituted with 0-5 R.sup.42; C.sub.3-6
carbocyclic group substituted with 0-3 R.sup.42, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is H, methyl, ethyl, methoxy, --OH, or --CF.sub.3; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 0-2 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3
R.sup.33, aryl substituted with 0-5 R.sup.33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.8 is selected from --OH, --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 1-2 R.sup.11, C.sub.2-4 alkenyl substituted with 0-2 R.sup.11, C.sub.2-4 alkynyl substituted with 0-1
R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3
R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.15, C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 alkoxy, (C.sub.1-4 haloalkyl) oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkenyl substituted with 0-1 R.sup.12a, C.sub.2-4
alkynyl substituted with 0-1 R.sup.12a, C.sub.3-6 cycloalkyl substituted with 0-3 R.sup.13, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4
heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12a, each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4
alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of one N, two N, three N, one N one O, and one N one S, wherein said bicyclic heterocyclic ring system is unsaturated or partially saturated, wherein said bicyclic heterocyclic ring system is substituted with 0-2 R.sup.16; R.sup.14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.15, at each occurrence, is independently selected from H, methyl, ethyl propyl, and butyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.31, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, methyl, ethyl, and propyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6
cycloalkyl, C.sub.3-4 haloalkyl, C.sub.1-4 haloalkyl-oxy-, C.sub.1-4 alkyloxy-, C.sub.1-4 alkylthio-, C.sub.1-4 alkyl-C(.dbd.O)--, C.sub.1-4 alkyl-C(.dbd.O)NH--, C.sub.1-4 alkyl-OC(.dbd.O)--, C.sub.1-4 alkyl-C(.dbd.O)O--, C.sub.3-6 cycloalkyl-oxy-, C.sub.3-6 cycloalkylmethyl-oxy-; C.sub.1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butyoxy; and C.sub.2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, and C.sub.1-3 alkyl; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, C.sub.3-6 cycloalkyl, and C.sub.1-3 al R.sup.43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl; k is 1; m is 1; and n is 1 or 2.
7. A compound of claim 1 wherein X is --O--; R.sup.1 is selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-4 cycloalkyl, C.sub.1-3 alkyl substituted with 0-1 R.sup.2, C.sub.2-3 alkenyl substituted with 0-1 R.sup.2, and C.sub.2-3 alkynyl substituted with 0-1 R.sup.2, R.sup.2, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, phenyl substituted with 0-5 R.sup.42; C.sub.3-6 carbocyclic group substituted with 0-3 R.sup.41, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is H, methyl, ethyl, methoxy, --OH, or --CF.sub.3; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, F, Cl, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --OCF.sub.3, --CN, and --NO.sub.2, R.sup.8 is selected from --OH, --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.1-4 alkyl substituted with 1-2 R.sup.11, C.sub.2-4 alkenyl substituted with 0-2 R.sup.11, C.sub.2-4 alkynyl substituted with 0-1 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from --CN, --NO.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 alkoxy, (C.sub.1-4 haloalkyl) oxy, C.sub.3-10 cycloalkyl substituted with 0-2 R.sup.33, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, and 5-6 membered heterocyclic ring system containing 1, 2, or 3 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl substituted with 0-1 R.sup.12a, C.sub.2-4 alkenyl substituted with 0-1
R.sup.12a, C.sub.2-4 alkynyl substituted with 0-1 R.sup.12a, C.sub.3-6 cycloalkyl substituted with 0-3 R.sup.33, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.12a, each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and b 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4
alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is benzimidazolyl, benzimidazolinyl, benztriazolyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, and dioxobenzthiazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R.sup.16; R.sup.14, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.15, at each occurrence, is independently selected from H, methyl, ethyl propyl, and butyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.31, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, methyl, ethyl, and propyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, --C(.dbd.O)H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.3-4 haloalkyl, C.sub.1-4 haloalkyl-oxy-, C.sub.1-4 alkyloxy-, C.sub.1-4 alkylthio-, C.sub.1-4 alkyl-C(.dbd.O)--, C.sub.1-4
alkyl-C(.dbd.O)NH--, C.sub.1-4 alkyl-OC(.dbd.O)--, C.sub.1-4 alkyl-C(.dbd.O)O--, C.sub.3-6 cycloalkyl-oxy-, C.sub.3-6 cycloalkylmethyl-oxy-; C.sub.1-6 alkyl substituted with OH, methoxy, ethoxy, propoxy, or butyoxy; and C.sub.2-6 alkenyl substituted with OH, methoxy, ethoxy, propoxy, or butoxy; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, and C.sub.1-3 alkyl; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-3 alkoxy, C.sub.1-3 haloalkyl, C.sub.3-6 cycloalkyl, and C.sub.1-3 alkyl; R.sup.43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from from H, methyl, ethyl, propyl, and butyl; k is 1; m is 1; and n is 1 or 2.
8. A compound of claim 1 wherein: X is --O--; R.sup.1 is selected from H, C.sub.1-5 alkyl substituted with 0-1 R.sup.2, C.sub.2-5 alkenyl substituted with 0-1 R.sup.2, and C.sub.2-3 alkynyl substituted with 0-1 R.sup.2; R.sup.2 is C.sub.3-6
cycloalkyl; R.sup.5 is H, methyl, ethyl, or propyl; R.sup.6a is H, methyl, or ethyl; R.sup.6b is H; R.sup.7 and R.sup.9, at each occurrence, are independently selected from H, F, Cl, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --OCF.sub.3, --CN, and --NO.sub.2, R.sup.8 is selected from methyl substituted with R.sup.11; ethenyl substituted with R.sup.11; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from phenyl-substituted with 0-5 fluoro; 2-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 2-(H.sub.3CC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(HC(.dbd.O))-phenyl-substituted with R.sup.33;
2-(H.sub.3CCH(OH))-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH.sub.2CH(OH))-phenyl substituted with R.sup.33; 2-(HOCH.sub.2)-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2)-phenyl-substituted with R.sup.33;
2-(HOCH.sub.3CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3COCH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3COCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH(OMe))-phenyl-substituted with R.sup.33;
2-(H.sub.3COC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-((MeOC.dbd.O)CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-(methyl)-phenyl-substituted with R.sup.33; 2-(ethyl)-phenyl-substituted with R.sup.33; 2-(i-propyl)-phenyl-substituted with R.sup.33; 2-(F.sub.3C)-phenyl-substituted with R.sup.33; 2-(NC)-phenyl-substituted with R.sup.33; 2-(H.sub.3CO)-phenyl-substituted with R.sup.33; 2-(fluoro)-phenyl-substituted with R.sup.33;
2-(chloro)-phenyl-substituted with R.sup.33; 3-(NC)-phenyl-substituted with R.sup.33; 3-(H.sub.3CO)-phenyl-substituted with R.sup.33; 3-(fluoro)-phenyl-substituted with R.sup.33; 3-(chloro)-phenyl-substituted with R.sup.33; 4-(NC)-phenyl-substituted with R.sup.33; 4-(fluoro)-phenyl-substituted with R.sup.33; 4-(chloro)-phenyl-substituted with R.sup.33; 4-(H.sub.3CS)-phenyl-substituted with R.sup.33; 4-(H.sub.3CO)-phenyl-substituted with R.sup.33; 4-(ethoxy)-phenyl-substituted with R.sup.33;
4-(i-propoxy)-phenyl-substituted with R.sup.33; 4-(i-butoxy)-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 4-((H.sub.3C).sub.2CHC(.dbd.O))-phenyl-substituted with R.sup.33;
4-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 4-(H.sub.3CC(.dbd.O)-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 4-((H.sub.3C).sub.2CHCH(OH)-phenyl-substituted with R.sup.33;
4-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH(OH))-phenyl-substituted with R.sup.33; 4-(cyclopropyloxy)-phenyl-substituted with R.sup.33; 4-(cyclobutyloxy)-phenyl-substituted with R.sup.33; and
4-(cyclopentyloxy)-phenyl-substituted with R.sup.33; R.sup.12 is selected from phenyl-substituted with 0-5 fluoro; 2-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 2-(H.sub.3CC(.dbd.O))-phenyl-substituted with R.sup.33;
2-(HC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH(OH))-phenyl substituted with R.sup.33; 2-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2)-phenyl-substituted with R.sup.33;
2-(HOCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3COCH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3COCH.sub.2CH.sub.2)-phenyl-substituted with R.sup.33; 2-(H.sub.3CCH(OMe))-phenyl-substituted with R.sup.33;
2-(H.sub.3COC(.dbd.O))-phenyl-substituted with R.sup.33; 2-(HOCH.sub.2CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-((MeOC.dbd.O)CH.dbd.CH)-phenyl-substituted with R.sup.33; 2-(methyl)-phenyl-substituted with R.sup.33; 2-(ethyl)-phenyl-substituted with R.sup.33; 2-(i-propyl)-phenyl-substituted with R.sup.33; 2-(F.sub.3C)-phenyl-substituted with R.sup.33; 2-(NC)-phenyl-substituted with R.sup.33; 2-(H.sub.3CO)-phenyl-substituted with R.sup.33; 2-(fluoro)-phenyl-substituted with R.sup.33;
2-(chloro)-phenyl-substituted with R.sup.33; 3-(NC)-phenyl-substituted with R.sup.33; 3-(H.sub.3CO)-phenyl-substituted with R.sup.33; 3-(fluoro)-phenyl-substituted with R.sup.33; 3-(chloro)-phenyl-substituted with R.sup.33; 4-(NC)-phenyl-substituted with R.sup.33; 4-(fluoro)-phenyl-substituted with R.sup.33; 4-(chloro)-phenyl-substituted with R.sup.33; 4-(H.sub.3CS)-phenyl-substituted with R.sup.33; 4-(H.sub.3CO)-phenyl-substituted with R.sup.33; 4-(ethoxy)-phenyl-substituted with R.sup.33;
4-(i-propoxy)-phenyl-substituted with R.sup.33; 4-(i-butoxy)-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 4-((H.sub.3C).sub.2CHC(.dbd.O) )-phenyl-substituted with R.sup.33;
4-(H.sub.3CCH.sub.2C(.dbd.O))-phenyl-substituted with R.sup.33; 4-(H.sub.3CC(.dbd.))-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH.sub.2CH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 4-((H.sub.3C).sub.2CHCH(OH))-phenyl-substituted with R.sup.33;
4-(H.sub.3CCH.sub.2CH(OH))-phenyl-substituted with R.sup.33; 4-(H.sub.3CCH(OH))-phenyl-substituted with R.sup.33; 4-(cyclopropyloxy)-phenyl-substituted with R.sup.33; 4-(cyclobutyloxy)-phenyl-substituted with R.sup.33; and
4-(cyclopentyloxy)-phenyl-substituted with R.sup.33; R.sup.13 is H, methyl, or ethyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring selected from pyrrolyl, pyrrolidinyl, imidazolyl, piperidinyl, piperizinyl, methylpiperizinyl, and morpholinyl; alternatively, R.sup.12 and R.sup.13 when attached to N may be combined to form a 9- or 10-membered bicyclic heterocyclic ring system containing form 1-3 heteroatoms selected from the group consisting of N, O, and S; wherein said bicyclic heterocyclic ring system is selected from indolyl, indolinyl, indazolyl, benzimidazolyl, benzimidazolinyl, and benztriazolyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, and dioxobenzthiazolyl; wherein said bicyclic heterocyclic ring system is substituted with 0-1 R.sup.16; R.sup.15 is H, methyl, ethyl, propyl, or butyl; R.sup.16, at each occurrence, is independently selected from H, OH, F, Cl, CN, NO.sub.2, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, and trifluoromethoxy; R.sup.33, at each occurrence, is independently selected from H, F, Cl, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --OCF.sub.3, --CN, and --NO.sub.2; k is 1; m is 1; and n is 1 or 2.
9. A compound of claim 2 of Formula ##STR00047## wherein: b is a single bond; X is --S-- or --O--; R.sup.1 is selected from hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, n-hexyl, 2-propyl, 2-butyl, 2-pentyl, 2-hexyl,
2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 2-methylpentyl, 3-methylbutyl, 4-methylpentyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-propenyl, 2-methyl-2-propenyl, trans-2-butenyl, 3-methyl-butenyl, 3-butenyl, trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl, 4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl, trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, benzyl,
2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 2,5-dimethylbenzyl, 2,4-dimethylbenzyl, 3,5-dimethylbenzyl, 2,4,6-trimethyl-benzyl, 3-methoxy-benzyl, 3,5-dimethoxy-benzyl, pentafluorobenzyl, 2-phenylethyl, 1-phenyl-2-propyl, 4-phenylbutyl,
4-phenylbenzyl, 2-phenylbenzyl, (2,3-dimethoxy-phenyl)C(.dbd.O)--, (2,5-dimethoxy-phenyl)C(.dbd.O)--, (3,5-dimethoxy-phenyl)C(.dbd.O)--, cyclopropyl-C(.dbd.O)--, isopropyl-C(.dbd.O)--, ethyl-CO.sub.2--, propyl-CO.sub.2--, t-butyl-CO.sub.2--,
2,6-dimethoxy-benzyl, 2,4-dimethoxy-benzyl, 2,4,6-trimethoxy-benzyl, 2,3-dimethoxy-benzyl, 2,4,5-trimethoxy-benzyl, 2,3,4-trimethoxy-benzyl, 3,4-dimethoxy-benzyl, 3,4,5-trimethoxy-benzyl, (4-fluoro-phenyl)ethyl, --CH.dbd.CH.sub.2, --CH.sub.2--CH.dbd.CH.sub.2, --CH.dbd.CH--CH.sub.3, --C.dbd.CH, --C.dbd.CH--CH.sub.3, and --CH.sub.2C.dbd.--CH; R.sup.8 is selected from cyano, nitro, trifluoromethoxy, phenyl, methylC(.dbd.)--, ethylC(.dbd.)--, propylC(.dbd.O)--, isopropylC(.dbd.O)--, butylC(.dbd.O)--, phenylC(.dbd.O)--, methylCO.sub.2--, ethylCO.sub.2--, propylCO.sub.2--, isopropylCO.sub.2--, butylCO.sub.2--, phenylCO.sub.2--, dimethylamino-S(.dbd.O)--, diethylamino-S(.dbd.O)--, dipropylamino-S(.dbd.O)--, di-isopropylamino-S(.dbd.O)--, dibutylamino-S(.dbd.O)--, diphenylamino-S(.dbd.O)--, dimethylamino-SO.sub.2--, diethylamino-SO.sub.2--, dipropylamino-SO.sub.2--, di-isopropylamino-SO.sub.2--, dibutylamino-SO.sub.2--, diphenylamino-SO.sub.2--, dimethylamino-C(.dbd.O)--, diethylamino-C(.dbd.O)--, dipropylamino-C(.dbd.O)--, di-isopropylamino-C(.dbd.O)--, dibutylamino-C(.dbd.O)--, diphenylamino-C(.dbd.O)--, 2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-cyanophenyl, 2-methylphenyl,
2-trifluoromethylphenyl, 2-methoxyphenyl, 2-trifluoromethoxyphenyl, 3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl, 3-cyanophenyl, 3-methylphenyl, 3-ethylpropyl, 3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl,
3-isopropoxyphenyl, 3-trifluoromethoxyphenyl, 3-thiomethoxyphenyl, 4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl, 4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl, 4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl,
4-isopropoxyphenyl, 4-trifluoromethoxyphenyl, 4-thiomethoxyphenyl, 2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl, 2,3-ditrifluoromethylphenyl-2,3-dimethoxyphenyl, 2,3-ditrifluoromethoxyphenyl, 2,4-dichlorophenyl, 2,4-difluorophenyl,
2,4-dimethylphenyl, 2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl, 2,4-ditrifluoromethoxyphenyl, 2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl, 2,5-trifluoromethylphenyl, 2,5-dimethoxyphenyl, 2,5-ditrifluoromethoxyphenyl,
2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl, 2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl, 2,6-ditrifluoromethoxyphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,4-dimethylphenyl, 3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl,
3,4-ditrifluoromethoxyphenyl, 2,4,6-trichlorohenyl, 2,4,6-trifluorophenyl, 2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl, 2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl, 2-chloro-4-CF.sub.3-phenyl, 2-fluoro-3-chloro-phenyl,
2-chloro-4-CF.sub.3-phenyl, 2-chloro-4-methoxy-phenyl, 2-methoxy-4-isopropyl-butyl, 2-CF.sub.3-4-methoxy-phenyl, 2-methyl-4-methoxy-5-fluoro-phenyl, 2-methyl-4-methoxy-phenyl, 2-chloro-4-CF.sub.3O-phenyl, 2,4,5-trimethyl-phenyl,
2-methyl-4-chloro-phenyl, methyl-C(.dbd.O)NH--, ethyl-C(.dbd.O)NH--, propyl-C(.dbd.O)NH--, isopropyl-C(.dbd.O)NH--, butyl-C(.dbd.O)NH--, phenyl-C(.dbd.O)NH--, 4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl, 2-thiophenyl, 2-naphthyl;
2-Me-4-F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl, 2-Me-3-Cl-phenyl, 3-NO.sub.2-phenyl, 2-NO.sub.2-phenyl, 2-Cl-3-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl, 2-Cl-6-F-phenyl, 2-Cl-4-(CHF.sub.2)O-phenyl, 2,4-diMeO-6-F-phenyl, 2-CF.sub.3-6-F-phenyl,
2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl, 2,3,4-triF-phenyl, 2,6-diF-4-Cl-phenyl, 2,3,4,6-tert-F-phenyl, 2,3,4,5,6-pentaF-phenyl, 2-CF.sub.3-4-EtO-phenyl, 2-CF.sub.3-4-iPrO-phenyl, 2-CF.sub.3-4-Cl-phenyl, 2-CF.sub.3-4-F-phenyl, 2-Cl-4-EtO-phenyl,
2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl, 2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl, 2-CHO(OMe)Me-4-MeO-phenyl, 2-C(.dbd.O)Me-4-MeO-phenyl, 2-CH.sub.2(OH)-4-MeO-phenyl, 2-CH.sub.2(OMe)-4-MeO-phenyl, 2-CH(OH)Et-4-MeO-phenyl, 2-C(.dbd.O)Et-4-MeO-phenyl, (Z)-2-CH.dbd.CHCO.sub.2Me-4-MeO-phenyl, 2-CH.sub.2CH.sub.2CO.sub.2Me-4-MeO-phenyl, (Z)-2-CH.dbd.CHCH.sub.2(OH)-4-MeO-phenyl, (E)-2-CH.dbd.CHCO.sub.2Me-4-MeO-phenyl, (E)-2-CH.dbd.CHCH.sub.2(OH)-4-MeO-phenyl, 2-CH.sub.2CH.sub.2OMe-4-MeO-phenyl,
2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl, (2-Cl-phenyl)-CH.dbd.CH--, (3-Cl-phenyl)-CH.dbd.CH--, (2,6-diF-phenyl)-CH.dbd.CH--, --CH.sub.2CH.dbd.CH.sub.2, phenyl-CH.dbd.CH--, (2-Me-4-MeO-phenyl)-CH.dbd.CH--, cyclohexyl, cyclopentyl, cyclohexylmethyl, --CH.sub.2CH.sub.2CO.sub.2Et, --(CH.sub.2).sub.3CO.sub.2Et, --(CH.sub.2).sub.4CO.sub.2Et, benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl, 3-MeO-benzyl, 3-OH-benzyl, 2-MeO-benzyl, 2-OH-benzyl, 2-CO.sub.2Me-3-MeO-phenyl, 2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl,
2-CF.sub.3-4-CN-phenyl, 3-CHO-phenyl, 3-CH.sub.2(OH)-phenyl, 3-CH.sub.2(OMe)-phenyl, 3-CH.sub.2(NMe.sub.2)-phenyl, 3-CN-4-F-phenyl, 3-CONH.sub.2-4-F-phenyl, 2-CH.sub.2(NH.sub.2)-4-MeO-phenyl-, phenyl-NH--, (4-F-phenyl)-NH--, (2,4-diCl-phenyl)-NH--, phenyl-C(.dbd.O)NH--, benzyl-NH--, (2,4-Me-4-MeO-phenyl)-NH--, (2-F-4-MeO-phenyl)-NH--, (2-Me-4-F-phenyl)-NH--, phenyl-S--, --NMe.sub.2, 1-pyrrolidinyl, and -N(tosylate).sub.2, R.sup.7 and R.sup.9, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, and trifluoromethoxy; m is 1; and n is 1 or 2.
10. A compound of claim 9 of Formula (II) ##STR00048## wherein: b is a single bond, wherein the bridge hydrogens are in a cis position; R.sup.1 is selected from hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, n-hexyl,
2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 3-methylpentyl, 3-methylbutyl, 4-methylphenyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-propyl, 2-methyl-2-propenyl, trans-2-butenyl,
3-methyl-butenyl, 3-butenyl, trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl, 4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl, trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, --CH.dbd.CH.sub.2, --CH.sub.2--CH.dbd.CH.sub.2, --CH.dbd.CH--CH.sub.3, --C.ident.CH, --C.ident.C--CH.sub.3, --CH.dbd.CH.sub.2, --CH.sub.2--CH.dbd.CH.sub.2, --CH.dbd.CH--CH.sub.3, --C.ident.--CH, --C.ident.--C--CH.sub.3, and --CH.sub.2--CH.ident.CH; R.sup.7 and R.sup.9, at each occurrence, are independently selected from hydrogen, fluoro, methyl, trifluoromethyl, and methoxy; R.sup.8 is selected from cyano, nitro, trifluoromethoxy, phenyl, methylC(.dbd.O)--, ethylC(.dbd.O)--, propylC(.dbd.O)--, isopropylC(.dbd.O)--, butylC(.dbd.O)--, phenylC(.dbd.)--, methylCo.sub.2--, ethylCO.sub.2--, propylCO.sub.2--, isopropylCO.sub.2--, butylCO.sub.2--, phenylCO.sub.2--, dimethylamino-S(.dbd.O)--, diethylamino-S(.dbd.O)--, dipropylamino-S(.dbd.O)--, di-isopropylamino-S(.dbd.O)--, dibutylamino-S(.dbd.O)--, diphenylamino-S(.dbd.O)--, dimethylamino-SO.sub.2--, diethylamino-SO.sub.2--, dipropylamino-SO.sub.2--, di-isopropylamino-SO.sub.2--, dibutylamino-SO.sub.2--, diphenylamino-SO.sub.2--, dimethylamino-C(.dbd.O)--, diethylamino-C(.dbd.O)--, dipropylamino-C(.dbd.O)--, di-isopropylamino-C(.dbd.O)--, dibutylamino-C(.dbd.O)--, diphenylamino-C(.dbd.O)--, 2-chlorophenyl, 2-fluorophenyl,
2-bromophenyl, 2-cyanophenyl, 2-methylphenyl, 2-trifluromethylphenyl, 2-methoxyphenyl, 2-trifluoromethoxyphenyl, 3-chlorophenyl, 3-fluorophenyl, 3-bromophenyl, 3-cyanophenyl, 3-methylphenyl, 3-ethylphenyl, 3-propylphenyl, 3-isopropylphenyl,
3-butylphenyl, 3-trifluoromethyl, 3-methoxyphenyl, 3-isopropoxyphenyl, 3-trifluoromethoxyphenyl, 3-thiomethoxyphenyl, 4-chlorophenyl, 4-fluorophenyl, 4-bromophenyl, 4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl, 4-propylphenyl, 4-isopropylphenyl,
4-butylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl, 4-isopropoxyphenyl, 4-trifluoromethoxyphenyl, 4-thiomethoxyphenyl, 2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl, 2,3-ditrifluoromethylphenyl, 2,3-dimethoxyphenyl,
2,3-ditrifluoromethoxyphenyl, 2,4-dichlorophenyl, 2,4-difluorophenyl, 2,4-dimethylphenyl, 2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl, 2,4-ditrifluoromethoxyphenyl, 2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl,
2,5-trifluoromethylphenyl, 2,5-dimethoxyphenyl, 2,5-ditrifluoromethoxyphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl, 2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl, 2,6-ditrifluoromethoxyphenyl, 3,4-dichlorophenyl,
3,4-difluorophenyl, 3,4-dimethylphenyl, 3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl, 3,4-ditrifluoromethoxyphenyl, 2,4,6-trichlorohenyl, 2,4,6-trifluorophenyl, 2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl, 2,4,6-trimethoxyphenyl,
2,4,6-trifluoromethoxyphenyl, 2-chloro-4-CF.sub.3-phenyl, 2-fluoro-3-chloro-phenyl, 2-chloro-4-CF.sub.3-phenyl, 2-chloro-4-methoxy-phenyl, 2-methoxy-4-isopropyl-butyl, 2-CF.sub.3-4-methoxy-phenyl, 2-methyl-4-methoxy-5-fluoro-phenyl,
2-methyl-4-methoxy-phenyl, 2-chloro-4-CF.sub.3O-phenyl, 2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl, methyl-C(.dbd.O)NH--, ethyl-C(.dbd.O)NH--, propyl-C(.dbd.O)NH--, isopropyl-C(.dbd.O)NH--, butyl-C(.dbd.O)NH--, phenyl-C(.dbd.O)NH--;
4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl, 2-thiophenyl, 2-naphthyl; 2-Me-4-F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl, 2-Me-3-Cl-phenyl, 3-NO.sub.2-phenyl, 2-NO.sub.2-phenyl, 2-Cl-3-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl,
2-Cl-6-F-phenyl, 2-Cl-4-(CHF.sub.2)O-phenyl, 2,4-diMeO-6-F-phenyl, 2-CF.sub.3-6-F-phenyl, 2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl, 2,3,4-triF-phenyl, 2,6-diF-4-Cl-phenyl, 2,3,4,6-tert-F-phenyl, 2,3,4,5,6-pentaF-phenyl, 2-CF.sub.3-4-EtO-phenyl,
2-CF.sub.3-4-iPrO-phenyl, 2-CF.sub.3-4-Cl-phenyl, 2-CF.sub.3-4-F-phenyl, 2-Cl-4-EtO-phenyl, 2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl, 2-CHO-4-MeO-phenyl, 2-CH(OH)Me-4-MeO-phenyl, 2-CHO(OMe)Me-4-MeO-phenyl, 2-C(.dbd.O)Me-4-MeO-phenyl,
2-CH.sub.2(OH)-4-MeO-phenyl, 2-CH.sub.2(OMe)-4-MeO-phenyl, 2-CH(OH)Et-4-MeO-phenyl, 2-C(.dbd.O)Et-4-MeO-phenyl, (Z)-2-CH.dbd.CHCO.sub.2Me-4-MeO-phenyl, 2-CH.sub.2CH.sub.2CO.sub.2Me-4-MeO-phenyl, (Z)-2-CH.dbd.CHCH.sub.2(OH)-4-MeO-phenyl, (E)-2-CH.dbd.CHCO.sub.2Me-4-MeO-phenyl, (E)-2-CH.dbd.CHCH.sub.2(OH)-4-MeO-phenyl, 2-CH.sub.2CH.sub.2OMe-4-MeO-phenyl, 2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl, (2-Cl-phenyl)-CH.dbd.CH--, (3-Cl-phenyl)-CH.dbd.CH--, (2,6-diF-phenyl)-CH.dbd.CH--, --CH.sub.2CH.dbd.CH.sub.2, phenyl-CH.dbd.CH--, (2-Me-4-MeO-phenyl)-CH.dbd.CH--, cyclohexyl, cyclopentyl, cyclohexylmethyl, --CH.sub.2CH.sub.2CO.sub.2Et, --(CH.sub.2).sub.3CO.sub.2Et, --(CH.sub.2).sub.4CO.sub.2Et, benzyl, 2-F-benzyl, 3-F-benzyl,
4-F-benzyl, 3-MeO-benzyl, 3-OH-benzyl, 2-MeO-benzyl, 2-OH-benzyl, 2-CO.sub.2Me-3-MeO-phenyl, 2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF.sub.3-4-CN-phenyl, 3-CHO-phenyl, 3-CH.sub.2(OH)-phenyl, 3-CH.sub.2(OMe)-phenyl, 3-CH.sub.2(NMe.sub.2)-phenyl,
3-CN-4-F-phenyl, 3-CONH.sub.2-4-F-phenyl, 2-CH.sub.2(NH.sub.2)-4-MeO-phenyl, phenyl-NH--, (4-F-phenyl)-NH--, (2,4-diCl-phenyl)-NH--, phenyl-C(.dbd.O)NH--, benzyl-NH--, (2,4-Me-4-MeO-phenyl)-NH--, (2-F-4-MeO-phenyl)-NH--, (2-Me-4-F-phenyl)-NH--, phenyl-S--, --NMe.sub.2, 1-pyrrolidinyl, and -N(tosylate).sub.2; and n is 1 or 2.
11. A compound of claim 9 of Formula (III) ##STR00049## wherein: b is a single bond, wherein the bridge hydrogens are in a cis position; R.sup.1 is selected from hydrogen, methyl, ethyl, n-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, n-hexyl,
2-propyl, 2-butyl, 2-pentyl, 2-hexyl, 2-methylpropyl, 2-methylbutyl, 2-methylpentyl, 2-ethylbutyl, 3-methylpentyl, 3-methylbutyl, 4-methylphenyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-propyl, 2-methyl-2-propenyl, trans-2-butenyl,
3-methyl-butenyl, 3-butenyl, trans-2-pentenyl, cis-2-pentenyl, 4-pentenyl, 4-methyl-3-pentenyl, 3,3-dichloro-2-propenyl, trans-3-phenyl-2-propenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, --CH.dbd.CH.sub.2, --CH.sub.2--CH.dbd.CH.sub.2, --CH.dbd.CH--CH.sub.3, --C.ident.CH, --C.ident.C--CH.sub.3, and --CH.sub.2--CH.ident.CH; R.sup.7 and R.sup.9, at each occurrence, are independently selected from hydrogen, fluoro, methyl, trifluoromethyl, and methoxy; and R.sup.8 is selected from cyano, nitro, trifluoromethoxy, phenyl, methylC(.dbd.O)--, ethylC(.dbd.O)--, propylC(.dbd.O)--, isopropylC(.dbd.O)--, butylC(.dbd.O)--, phenylC(.dbd.)--, methylCO.sub.2--, ethylCO.sub.2--, propylCO.sub.2--, isopropylCO.sub.2--, butylCO.sub.2--, phenylCO.sub.2--, dimethylamino-S(.dbd.O)--, diethylamino-S(.dbd.O)--, dipropylamino-S(.dbd.O)--, di-isopropylamino-S(.dbd.O)--, dibutylamino-S(.dbd.O)--, diphenylamino-S(.dbd.O)--, dimethylamino-SO.sub.2--, diethylamino-SO.sub.2--, dipropylamino-SO.sub.2--, di-isopropylamino-SO.sub.2--, dibutylamino-SO.sub.2--, diphenylamino-SO.sub.2--, dimethylamino-C(.dbd.O)--, diethylamino-C(.dbd.O)--, dipropylamino-C(.dbd.O)--, di-isopropylamino-C(.dbd.O)--, dibutylamino-C(.dbd.O)--, diphenylamino-C(.dbd.O)--, 2-chlorophenyl, 2-fluorophenyl, 2-bromophenyl, 2-cyanophenyl, 2-methylphenyl, 2- trifluoromethylphenyl, 2-methoxyphenyl, 2-trifluoromethoxyphenyl, 3-chlorophenyl,
3-fluorophenyl, 3-bromophenyl, 3-cyanophenyl, 3-methylphenyl, 3-ethylphenyl, 3-propylphenyl, 3-isopropylphenyl, 3-butylphenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 3-isopropoxyphenyl, 3-trifluoromethoxyphenyl, 3-thiomethoxyphenyl, 4-chlorophenyl,
4-fluorophenyl, 4-bromophenyl, 4-cyanophenyl, 4-methylphenyl, 4-ethylphenyl, 4-propylphenyl, 4-isopropylphenyl, 4-butylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl, 4-isopropoxyphenyl, 4-trifluoromethoxyphenyl, 4-thiomethoxyphenyl,
2,3-dichlorophenyl, 2,3-difluorophenyl, 2,3-dimethylphenyl, 2,3-ditrifluoromethylphenyl, 2,3-dimethoxyphenyl, 2,3-ditrifluoromethoxyphenyl, 2,4-dichlorophenyl, 2,4-difluorophenyl, 2,4-dimethylphenyl, 2,4-ditrifluoromethylphenyl, 2,4-dimethoxyphenyl,
2,4-ditrifluoromethoxyphenyl, 2,5-dichlorophenyl, 2,5-difluorophenyl, 2,5-dimethylphenyl, 2,5-ditrifluoromethylphenyl, 2,5-dimethoxyphenyl, 2,5-ditrifluoromethoxyphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylphenyl,
2,6-ditrifluoromethylphenyl, 2,6-dimethoxyphenyl, 2,6-trifluoromethoxyphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,4-dimethylphenyl, 3,4-ditrifluoromethylphenyl, 3,4-dimethoxyphenyl, 3,4-ditrifluoromethoxyphenyl, 2,4,6-trichlorophenyl,
2,4,6-trifluorophenyl, 2,4,6-trimethylphenyl, 2,4,6-trifluoromethylphenyl, 2,4,6-trimethoxyphenyl, 2,4,6-trifluoromethoxyphenyl, 2-chloro-4-CF.sub.3-phenyl, 2-fluoro-3-chloro-phenyl, 2-chloro-4-CF.sub.3-phenyl, 2-chloro-4-methoxy-phenyl,
2-methoxy-4-isopropyl-phenyl, 2-CF.sub.3-4-methoxy-phenyl, 2-methyl-4-methoxy-5-fluoro-phenyl, 2-methyl-4-methoxy-phenyl, 2-chloro-4-CF.sub.3O-phenyl, 2,4,5-trimethyl-phenyl, 2-methyl-4-chloro-phenyl, methyl-C(.dbd.O)NH--, ethyl-C(.dbd.O)NH--, propyl-C(.dbd.O)NH--, isopropyl-C(.dbd.O)NH--, butyl-C(.dbd.O)NH--, phenyl-C(.dbd.O)NH--, 4-acetylphenyl, 3-acetamidophenyl, 4-pyridyl, 2-furanyl, 2-thiophenyl, 2-naphthyl; 2-Me-5F-phenyl, 2-F-5-Me-phenyl, 2-MeO-5-F-phenyl, 2-Me-3-Cl-phenyl,
3-NO.sub.2-phenyl, 2-NO.sub.2-phenyl, 2-Cl-3-Me-phenyl, 2-Me-phenyl, 2-Me-4-EtO-phenyl, 2-Me-4-F-phenyl, 2-Cl-6-F-phenyl, 2-Cl-4-(CHF.sub.2)O-phenyl, 2,4-diMeO-6-F-phenyl, 2-CF.sub.3-6-F-phenyl, 2-MeS-phenyl, 2,6-diCl-4-MeO-phenyl, 2,3,4-triF-phenyl,
2,6-diF-5-Cl-phenyl, 2,3,4-tetraF-phenyl, 2,3,4,5,6-pentaF-phenyl, 2-CF.sub.3-4-EtO-phenyl, 2-CF.sub.3-iPrO-phenyl, 2-CF.sub.3-4-Cl-phenyl, 2-CF.sub.3-4-F-phenyl, 2-Cl-4-EtO-phenyl, 2-Cl-4-iPrO-phenyl, 2-Et-4-MeO-phenyl, 2-CHO-4-MeO-phenyl,
2-CH(OH)Me-4-MeO-phenyl, 2-CH(OMe)Me-4-MeO-phenyl, 2C(.dbd.O)Me-4-MeO-phenyl, 2-CH.sub.2(OH)-4-O-phenyl, 2-CH.sub.3(OMe)-phenyl, 2-CH(OH)Et-4-MeO-phenyl, 2-C(.dbd.O)Et-4-MeO-phenyl, (Z)-2-CH.dbd.CHCO.sub.2Me-4-MeO-phenyl,
2-CH.sub.2CH.sub.2CO.sub.2Me-4-MeO-phenyl, (Z)-2-CH.dbd.CHCH.sub.2(OH)-4-MeO-phenyl, (E)-2-CH.dbd.CHCO.sub.2Me-4-MeO-phenyl, (E)-2-CH.dbd.CHCH.sub.2(OH)-4-MeO-phenyl, 2-CH.sub.2C.sub.2OMe-4-MeO-phenyl, 2-F-4-MeO-phenyl, 2-Cl-4-F-phenyl, (2-Cl-phenyl)-CH.dbd.CH--, (3-Cl-phenyl)-CH.dbd.CH--, (2,6-diF-phenyl)-CH.dbd.CH--, --CH.sub.2CH.dbd.CH.sub.2, phenyl-CH.dbd.CH--, (2-Me-4-MeO-phenyl)CH.dbd.C--, cyclohexyl, cyclopentyl, cyclohexylmethyl, 13 CH.sub.2CH.sub.2CO.sub.2Et, --(CH.sub.2).sub.3CO.sub.2Et, --(CH.sub.2).sub.4CO.sub.2Et, benzyl, 2-F-benzyl, 3-F-benzyl, 4-F-benzyl, 3-MeO-benyzl, 3-OH-benzyl, 2-MeO-benzyl, 2-OH-benzyl, 2-CO.sub.2Me-3-MeO-phenyl, 2-Me-4-CN-phenyl, 2-Me-3-CN-phenyl, 2-CF.sub.3-4-CN-phenyl,
3-CHO-phenyl, 3-CH.sub.2(OH)-phenyl, 3-CH.sub.2(OMe)-phenyl, 3-CH.sub.2(NMe.sub.2)-phenyl, 3-CN-4-F-phenyl, 3-CONH.sub.2-4-F-phenyl, 2-CH.sub.2(NH.sub.2)-4-MeO-phenyl-, phenyl-NH--, (4-F-phenyl)-NH--, (2,4-diCl-phenyl)-NH--, phenyl-C(.dbd.O)NH--, benzyl-NH--, (2-Me-4-MeO-phenyl)-NH--, (2-F-4-MeO-phenyl)-NH--, (2-Me-4-F-phenyl)-NH--, phenyl-S--, --NM.sub.2, 1-pyrrolidinyl, and --N(tosylate)2; and n is 1 or 2.
12. A compound of formula (I): ##STR00050## or steroisomers or pharmaceutically acceptable salt forms thereof, wherein: b is a single bond; X is --O--, --S--, --S(.dbd.O)--, or --S(.dbd.O).sub.2--, R.sup.1 is selected from C.sub.1-6 alkyl substituted with Z, C.sub.2-6 alkenyl substituted with Z, C.sub.2-6 alkynyl substituted with Z, C.sub.3-6 cycloalkyl substituted with Z, aryl substituted with Z, 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z, C.sub.1-6 alkyl substituted with 1-2 R.sup.2, but R.sup.2 cannot be alkyl; C.sub.2-6 alkenyl substituted with 0-2 R.sup.2, C.sub.2-6 alkynyl substituted with 0-2 R.sup.2, aryl substituted with 0-2 R.sup.2, and 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with 0-2 R.sup.2, Z is selected from --CH(OH).sup.2, --C(ethylenedioxy)R.sup.2, --OR.sup.2, --SR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --C(O)N.sup.2R.sup.3, --NR.sup.3C(O)R.sup.2, --C(O)OR.sup.2, --OC(O)R.sup.2, --CH(.dbd.NR.sup.4)NR.sup.2R.sup.3, --NHC(.dbd.NR.sup.4)NR.sup.2R.sup.3, --S(O)R.sup.2, --S(O).sub.2R.sup.2, --S(O).sub.2NR.sup.2R.sup.3, and --NR.sup.3S(O).sub.2R.sup.2, R.sup.2, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, aryl substituted with 0-5 R.sup.42; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.41, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.3, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, and C.sub.3-4 alkoxy; alternatively, R.sup.2 and R.sup.3 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.4)--; R.sup.4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.5 is H, methyl, ethyl, propyl, or butyl; R.sup.6a is selected from H, --OH, --NR.sup.46R.sup.47, --CF.sub.3, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6 cycloalkyl, and aryl substituted with 0-3 R.sup.44; R.sup.6b is H; R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-8 alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.1-4 alkyl substituted with 0-2 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O)NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14)NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from H, halo, --CF.sub.3, --CN, --NO.sub.2, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-8 alkoxy, C.sub.3-10 cycloalkyl, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O)NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, (O)OR.sup.12, OC(O)R.sup.12, OC(O)OR.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14)NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O)NR.sup.12R.sup.13, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O)R.sup.12, and NR.sup.14S(O).sub.2R.sup.12, R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; p1 R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; R.sup.14, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; R.sup.31, at each occurrence, is independently selected from H, OH, halo, CF.sub.3SO.sub.2R.sup.45, NR.sup.46R.sup.47, methyl, ethyl, and propyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, SO.sub.2R.sup.45, NR.sup.46R.sup.47, C.sub.1-3 alkyl, C.sub.2-3 alkenyl, C.sub.2-3 alkynyl, C.sub.3-5 cycloalkyl, C.sub.1-3 haloalkyl, C.sub.1-3 haloalkyl-oxy-, C.sub.1-3 alkyloxy-, C.sub.1-3 alkylthio, C.sub.1-3 alkyl-C(.dbd.O)--, and C.sub.1-3 alkyl- C(.dbd.O)NH--; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, .dbd.O, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl C.sub.1-4 alkyl substituted with 0-1
R.sup.43, aryl substituted with 0-3 R.sup.42, and 5-10 membered heterocycle ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, SR.sup.45, NR.sup.46R.sup.47, OR.sup.48, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6
cycloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.45, aryl substituted with 0-3 R.sup.44, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.43 is C.sub.3-6 cycloalkyl or aryl substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, C.sub.1-4
alkyl, and C.sub.1-4 alkoxy; R.sup.45 is C.sub.1-4 alkyl; R.sup.46, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; R.sup.47, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, --C(.dbd.O)NHC(C.sub.1-4
alkyl), --SO.sub.2(C.sub.1-4 alkyl), --SO.sub.2(phenyl), --C(.dbd.O)O(C.sub.1-4 alkyl), --C(.dbd.O)(C.sub.1-4 alkyl), and --C(.dbd.O)H; R.sup.48, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, --C(.dbd.O)NH(C.sub.1-4 alkyl), --C(.dbd.O)O(C.sub.1-4 alkyl), --C(.dbd.O)(C.sub.1-4alkyl), and --C(.dbd.O)H; k is 1 or 2; m is 0, 1, or 2; and n is 1 or 2; provided when m is 0 or 1 then k is 1 or 2; provided when m is 2 then l is 1; provided that when b is a single bond; n is
1 or 2; m is 1; k is 1; X is O or S; and R.sup.1 is C.sub.1-4 alkyl or cyclopropyl, then R.sup.8 is a substituent other than H.
13. A compound of claim 12 wherein: X is --O-- or --S--; R.sup.1 is selected from C.sub.2-5 alkyl substituted with Z, C.sub.2-5 alkenyl substituted with Z, C.sub.2-5 alkynyl substituted with Z, C.sub.3-6 cycloalkyl substituted with Z, aryl substituted with Z, 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z; C.sub.1-5 alkyl substituted with 1-2 R.sup.2, but R.sup.2
cannot be alkyl; C.sub.2-5 alkenyl substituted with 0-2 R.sup.2, and C.sub.2-5 alkynyl substituted with 0-2 R.sup.2; Z is selected from --CH(OH)R.sup.2, --C(ethylenedioxy)R.sup.2, --OR.sup.2, --SR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --C(O)NR.sup.2R.sup.3, --NR.sup.3C(O)R.sup.2, --C(O)OR.sup.2, --OC(O)R.sup.2, CH(.dbd.NR.sup.4)NR.sup.2R.sup.3, --NHC(.dbd.NR.sup.4)NR.sup.2R.sup.3, --S(O)R.sup.2, --S(O)R.sub.2R.sup.2, --S(O).sub.2NR.sup.2R.sup.3, and --NR.sup.3S(O).sub.2R.sup.2; R.sup.3, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, aryl substituted with 0-5 R.sup.42; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.43, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.3, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4
alkynyl, and C.sub.1-4 alkoxy; alternatively, R.sup.2 and R.sup.3 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.6)--; R.sup.4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.5 is H, methyl, or ethyl; R.sup.6a is selected from H, --OH, --NR.sup.46R.sup.47, --CF.sub.3, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, and C.sub.3-6 cycloalkyl; R.sup.6b is H; R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --OCH.sub.3, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-4 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-6
alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.1-4 alkyl substituted with 0-2 R.sup.11, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; OR.sup.12, SR.sup.12, NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O)NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)OR.sup.12OC(O)R.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14)NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O).sub.2NR.sup.12R.sup.13, NR.sup.14S(O).sub.2R.sup.12, NR.sup.14S(O)R.sup.12, NR.sup.14S(O).sub.2R.sup.12, NR.sup.12C(O)R.sup.15, NR.sup.12C(O)OR.sup.15, NR.sup.12S(O).sub.2R.sup.15, and NR.sup.12C(O)NHR.sup.15; R.sup.11 is selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --OCH.sub.3, --CN, --NO.sub.2, --NR.sup.46R.sup.47, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 haloalkyl, C.sub.1-6 alkoxy, (C.sub.1-4 haloalkyl)oxy, C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, aryl substituted with 0-5 R.sup.33, 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the groups consisting of N, O, and S substituted with 0-3 R.sup.31, OR.sup.12, SR.sup.12NR.sup.12R.sup.13, C(O)H, C(O)R.sup.12, C(O)NR.sup.12R.sup.13, NR.sup.14C(O)R.sup.12, C(O)R.sup.12, OC(O)R.sup.12, CH(.dbd.NR.sup.14)NR.sup.12R.sup.13, NHC(.dbd.NR.sup.14)NR.sup.12R.sup.13, S(O)R.sup.12, S(O).sub.2R.sup.12, S(O).sub.2NR.sup.12R.sup.13, and NR.sup.14S(O).sub.2R.sup.12; R.sup.12, at each occurrence, is independently selected from C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, phenyl substituted with 0-5 R.sup.33; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.33, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.31; R.sup.13, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, and C.sub.2-4 alkynyl; alternatively, R.sup.12 and R.sup.13 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.14)--; R.sup.14, at each occurrence, is independently selected from H and C.sub.1-4 alkyl; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, methyl, and ethyl; R.sup.13, at each occurrence, is independently selected from H, OH, halo, CN, NO.sub.2, CF.sub.3, methyl, and ethyl; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, .dbd.O, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4
alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43, aryl substituted with 0-3 R.sup.42, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with
0-3 R.sup.44; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, SR.sup.45, NR.sup.46R.sup.47, OR.sup.48, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-6 alkenyl, C.sub.2-6
alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6 cycloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43, aryl substituted with 0-3 R.sup.44, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.43 is C.sub.3-6 cycloalkyl or aryl substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, C.sub.1-4 alkyl, and C.sub.1-4 alkoxy; R.sup.45 is C.sub.1-4 alkyl; R.sup.46, at each occurrence, is independently selected from H, and C.sub.1-3 alkyl; R.sup.47, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, --C(.dbd.O)NH(C.sub.1-4 alkyl), --SO.sub.2(C.sub.1-4 alkyl), --SO.sub.2(phenyl), --C(.dbd.O)O(C.sub.1-4 alkyl), --C(.dbd.O) (C.sub.1-4 alkyl), and --C(.dbd.O)H; R.sup.48, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, --C(.dbd.O)NH(C.sub.1-4 alkyl), --C(.dbd.O)O(C.sub.1-4 alkyl), --C(.dbd.O)(C.sub.1-4 alkyl), and --C(.dbd.O)H; k is 1 or 2; m is 0, 1, 2; and n is 1 or 2.
14. A compound of claim 12 wherein: X --O--; R.sup.1 is selected from C.sub.2-4 alkyl substituted with Z, C.sub.2-4 alkenyl substituted with Z, C.sub.2-4 alkynyl substituted with Z, C.sub.3-6 cycloalkyl substituted with Z, aryl substituted with Z, 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z; C.sub.2-4 alkyl substituted with 1-2 R.sup.2, but R.sup.2 is other than alkyl; and C.sub.2-4 alkenyl substituted with 0-2 R.sup.2; Z is selected from --CH(OH)R.sup.2, --C(ethylenedioxy)R.sup.2, --OR.sup.2, --SR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --C(O)NR.sup.2R.sup.3, --NR.sup.3C(O)R.sup.2, ----C(O)OR.sup.2, --S(O)R.sup.2, --S(O).sub.2R.sup.2, --S(O).sub.2NR.sup.2R.sup.3, and --NR.sup.3S(O).sub.2R.sup.2; R.sup.2, at each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.42; C.sub.3-10 carbocyclic group substituted with 0-3
R.sup.41, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.3, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, and C.sub.1-4 alkoxy; alternatively, R.sup.2 and R.sup.3 join to form a 5- or 6-membered ring optionally substituted with --O-- or --N(R.sup.4)--; R.sup.4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl, R.sup.5 is H; R.sup.6a is selected from H, --OH, --CF.sub.3, methyl, ethyl, propyl, butyl, methoxy, and ethoxy; R.sup.6b is H; R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --OCH.sub.3, --CN, --NO.sub.2, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy, (C.sub.1-3 haloalkyl) oxy, and C.sub.1-4 alkyl substituted with 0-2 R.sup.11; R.sup.11 is selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --OCH.sub.3, --CN, --NO.sub.2, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy, and (C.sub.1-3 haloalkyl)oxy; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, and methyl; R.sup.41, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, .dbd.O, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl substituted with 0-1
R.sup.43, aryl substituted with 0-3 R.sup.42, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, SR.sup.45, NR.sup.46R.sup.47, OR.sup.48, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6
cycloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43, aryl substituted with 0-3 R.sup.44, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; R.sup.43 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, --C(.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --SO.sub.2(methyl), --SO.sub.2(ethyl), --SO.sub.2(phenyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; R.sup.48, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, --C(.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; k is 1; m is 0, 1, or 2; and n is 1 or 2.
15. A compound of claim 12 wherein: X is --O--; R.sup.1 is selected from ethyl substituted with Z, propyl substituted with Z, butyl substituted with Z, propenyl substituted with Z, butenyl substituted with Z, ethyl substituted with R.sup.2, propyl substituted with R.sup.2, butyl substituted with R.sup.2, propenyl substituted with R.sup.2, and butenyl substituted with R.sup.2; provided that with respect to ethyl, propyl and butyl, R.sup.2 is other than alkyl; Z is selected from --CH(OH)R.sup.2, --OR.sup.2, --SR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --C(O)NR.sup.2R.sup.3, --NR.sup.3C(O)R.sup.2, C(O)OR.sup.2, --S(O)R.sup.2, --S(O).sub.2R.sup.2, --S(O).sub.2NR.sup.2R.sup.3, and --NR.sup.3S(O).sub.2R.sup.2; R.sup.2, at each occurrence, is independently selected from phenyl substituted with 0-3 R.sup.42; naphthyl substituted with 0-3 R.sup.42; cyclopropyl substituted with 0-3 R.sup.41; cyclobutyl substituted with 0-3 R.sup.41; cyclopentyl substituted with 0-3 R.sup.41; cyclohexyl substituted with 0-3 R.sup.41; pyridyl substituted with 0-3 R.sup.41; indolyl substituted with 0-3 R.sup.41; indolinyl substituted with 0-3 R.sup.41; benzimidazolyl substituted with 0-3 R.sup.41; benzotriazolyl substituted with 0-3
R.sup.41; benzothienyl substituted with 0-3 R.sup.41; benzofuranyl substituted with 0-3 R.sup.41; phthalimid-1-yl substituted with 0-3 R.sup.41; inden-2-yl substituted with 0-3 R.sup.41; 2,3-dihydro-1H-inden-2-yl substituted 0-3 R.sup.41; indazolyl substituted with 0-3 R.sup.41; tetrahydroquinolinyl substituted with 0-3 R.sup.41; and tetrahydro-isoquinolinyl substituted with 0-3 R.sup.41; R.sup.3, at each occurrence, is independently selected from H, methyl, and ethyl; R.sup.3 is H; R.sup.6a is selected from H, --OH, methyl, and methoxy; R.sup.6b is H; R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from H, F, Cl, methyl, ethyl, methoxy, --CF.sub.3, and --OCF.sub.3; R.sup.41, at each occurrence, is independently selected from H, F, Cl, Br, OH, CF.sub.3, NO.sub.2, CN, .dbd.O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy; R.sup.42, at each occurrence, is independently selected from H, F, Cl, Br, OH, CF.sub.3, SO.sub.2R.sup.45, SR.sup.45, NR.sup.46R.sup.47, OR.sup.48, NO.sub.2, CN, .dbd.O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, --C(.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --SO.sub.2(methyl), --SO.sub.2(ethyl), --SO.sub.2(phenyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; R.sup.48, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, --C(.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; k is 1; m is 0, 1, or 2; and n is 1 or 2.
16. A compound of claim 12 wherein: X is --S--; R.sup.1 is selected from C.sub.2-4 alkyl substituted with Z, C.sub.2-4 alkenyl substituted with Z, C.sub.2-4 alkynyl substituted with Z, C.sub.3-6 cycloalkyl substituted with Z, aryl substituted with Z, 5-6 membered heterocyclic ring system containing at least one heteroatom selected from the group consisting of N, O, and S, said heterocyclic ring system substituted with Z; C.sub.2-4 alkyl substituted with 1-2 R.sup.2, where R.sup.2 is other than alkyl; and C.sub.2-4 alkenyl substituted with 0-2 R.sup.2; Z is selected from --CH(OH)R.sup.2, --C(ethylenedioxy)R.sup.2, --OR.sup.2, --SR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --S(O)R.sup.2, --S(O)R.sup.2, --S(O).sub.2NR.sup.2R.sup.3, and --NR.sup.3S(O).sub.2R.sup.2; R.sup.2, at each occurrence, is independently selected from phenyl substituted with 0-5 R.sup.42; C.sub.3-10 carbocyclic group substituted with 0-3 R.sup.41, and 5-10 membered heterocyclic ring system containing from 1-4
heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.41; R.sup.3, at each occurrence, is independently selected from H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, and C.sub.1-4 alkoxy; alternatively, R.sup.2 and R.sup.3 join to form a 5- or 6-membered ring optionally substituted with --O-- or N(R.sup.4)--; R.sup.4, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.5 is H; R.sup.6a is selected from H, --OH, --CF.sub.3, methyl, ethyl, propyl, butyl, methoxy, and ethoxy; R.sup.6b is H; R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --OCH.sub.3, --CN, --NO.sub.2, C.sub.1-4
alkyl, C.sub.3-4 haloalkyl, C.sub.1-4 alkoxy, (C.sub.1-3 haloalkyl) oxy, and C.sub.1-4 alkyl substituted with 0-2 R.sup.11; R.sup.11 is selected from H, halo, --CF.sub.3, --OCF.sub.3, --OH, --OCH.sub.3, --CN: --NO.sub.2, C.sub.1-4 alkyl, C.sub.1-4
haloalkyl, C.sub.1-4 alkoxy, and (C.sub.1-3 haloalkyl)oxy; R.sup.33, at each occurrence, is independently selected from H, OH, halo, CF.sub.3, and methyl; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, NR.sup.46R.sup.47, NO.sub.2, CN, .dbd.O, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43, aryl substituted with 0-3 R.sup.42, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.42, at each occurrence, is independently selected from H, CF.sub.3, halo, OH, CO.sub.2H, SO.sub.2R.sup.45, SR.sup.45, NR.sup.46R.sup.47, OR.sup.48, NO.sub.2, CN, CH(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.3-6 cycloalkyl, C.sub.1-4 alkyl substituted with 0-1 R.sup.43, aryl substituted with
0-3 R.sup.44, and 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R.sup.44; R.sup.43 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, or pyridyl, each substituted with 0-3 R.sup.44; R.sup.44, at each occurrence, is independently selected from H, halo, --OH, NR.sup.46R.sup.47, CO.sub.2H, SO.sub.2R.sup.45, --CF.sub.3, --OCF.sub.3, --CN, --NO.sub.2, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl, R.sup.47, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, --C(.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --SO.sub.2(methyl), --SO.sub.2(ethyl), --SO.sub.2(phenyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; R.sup.49, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, --C(.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --C(.dbd.O)O(methyl),-- C(.dbd.O)O(ethyl), --C(.dbd.O)O(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.)H; k is 1; m is 0, 1 or 2; and n is
1 or 2.
17. A compound of claim 12 wherein: X is --O--; R.sup.1 is selected from ethyl substituted with Z; propyl substituted with Z; butyl substituted with Z; propenyl substituted with Z; butenyl substituted with Z; ethyl substituted with R.sup.2; propyl substituted with R.sup.2; butyl substituted with R.sup.2; provided that with respect to ethyl, propyl and butyl, R.sup.2 is other than alkyl; propenyl substituted with R.sup.2; and butenyl substituted with R.sup.2; Z is selected from --CH(OH)R.sup.2, --OR.sup.2, --SR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --(O)NR.sup.2R.sup.3, --NR.sup.3C(O)R.sup.2, --C(O)OR.sup.2, --S(O)R.sup.2, --S(O).sub.2R.sup.2, --S(O).sub.2NR.sup.2R.sup.3, and --NR.sup.3S(O).sub.2R.sup.2; R.sup.2, at each occurrence, is independently selected from phenyl substituted with 0-3 R.sup.42, naphthyl substituted with 0-3 R.sup.42; cyclopropyl substituted with 0-3 R.sup.41; cyclobutyl substituted with 0-3 R.sup.41; cyclopentyl substituted with 0-3
R.sup.41; cyclohexyl substituted with 0-3 R.sup.41; pyridyl substituted with 0-3 R.sup.41; indolyl substituted with 0-3 R.sup.41; indolinyl substituted with 0-3 R.sup.41; benzimidazolyl substituted with 0-3 R.sup.41; benzotriazolyl substituted with
0-3 R.sup.41; benzothienyl substituted with 0-3 R.sup.41; benzofuranyl substituted with 0-3 R.sup.41; phthalimid-1-yl substituted with 0-3 R.sup.41; inden-2-yl substituted with 0-3 R.sup.41; 2,3-dihydro-1H-inden-2-yl substituted 0-3 R.sup.41; indazolyl substituted with 0-3 R.sup.41; tetrahydroquinolinyl substituted with 0-3 R.sup.41; and tetrahydro-isoquinolinyl substituted with 0-3 R.sup.41; R.sup.3, at each occurrence, is independently selected from H, methyl, and ethyl; R.sup.5 is H; R.sup.6a is selected from H, --OH, methyl, and methoxy; R.sup.6b is H; R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from H, F, Cl, methyl, ethyl, methoxy, --CF.sub.3, and --OCF.sub.3, R.sup.41, at each occurrence, is independently selected from H, F, Cl, Br, OH, CF.sub.3, NO.sub.2, CN, .dbd.O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy; R.sup.42, at each occurrence, is independently selected from H, F, Cl, Br, OH, CF.sub.3, SO.sub.2R.sup.45, SR.sup.45, NR.sup.46R.sup.47, OR.sup.48, NO.sub.2, CN, .dbd.O, methyl, ethyl, propyl, butyl, methoxy, and ethoxy; R.sup.45 is methyl, ethyl, propyl, or butyl; R.sup.46, at each occurrence, is independently selected from H, methyl, ethyl, propyl, and butyl; R.sup.47, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, --(C.dbd.O)NH(methyl), --C(.dbd.O)NH(ethyl), --SO.sub.2(methyl), --SO.sub.2(ethyl), --SO.sub.2(phenyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; R.sup.48, at each occurrence, is independently selected from H, methyl, ethyl, n-propyl, i-propyl, --C(.dbd.O)NH (methyl), --C(.dbd.O)H(ethyl), --C(.dbd.O)O(methyl), --C(.dbd.O)O(ethyl), --C(.dbd.O)(methyl), --C(.dbd.O)(ethyl), and --C(.dbd.O)H; k is 1; m is 0, 1, or 2; and n is 1 or 2.
18. A compound of claim 12 of Formula (I-a) ##STR00051## wherein: b is a single bond; X is --S-- or --O--; R.sup.1 is selected from --C(CH.sub.2).sub.3C(.dbd.O)(4-fluoro-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-bromo-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-methyl-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-methoxy-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-(3,4-dichloro-phenyl)phenyl), --(CH.sub.2).sub.3C(.dbd.O)(3-methyl-4-fluoro-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2,3-dimethoxy-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-chloro-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(3-methyl-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-t-butyl-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(3,4-difluoro-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-methoxy-5-fluoro-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(4-fluoro-1-naphthyl), --(CH.sub.2).sub.3C(.dbd.O)(benzyl), --(CH.sub.2).sub.3C(.dbd.O)(4-pyridyl), --(CH.sub.2).sub.3C(.dbd.O)(3-pyridyl), --(CH.sub.2).sub.3CH(OH)(4-fluoro-phenyl), --(CH.sub.2).sub.3CH(OH)(4-pyridyl), --(CH.sub.2).sub.3CH(OH)(2,3-dimethoxy-phenyl), --(CH.sub.2).sub.3S(3-fluoro-phenyl), --(CH.sub.2).sub.3S(4-fluoro-phenyl), --(CH.sub.2).sub.3S(.dbd.O)(4-fluoro-phenyl), --(CH.sub.2).sub.3SO.sub.2(3-fluoro-phenyl), --(CH.sub.2).sub.3SO.sub.2(4-fluoro-phenyl), --(CH.sub.2).sub.3O(4-fluoro-phenyl), --(CH.sub.2).sub.3O(phenyl), --(CH.sub.2).sub.3O(3-pyridyl), --(CH.sub.2).sub.3O(4-pyridyl), --(CH.sub.2).sub.3O(2-NH.sub.2-phenyl), --(CH.sub.2).sub.2O(2-NH.sub.2-5-F-phenyl), --(CH.sub.2).sub.3O(2-NH.sub.2-4-F-phenyl), --(CH.sub.2).sub.3O(2-NH.sub.2-3-F-phenyl), --(CH.sub.2).sub.3O(2-NH.sub.2-4-Cl-phenyl), --(CH.sub.2).sub.3O(2-NH.sub.2-4-OH-phenyl), --(CH.sub.2).sub.3O(2-NH.sub.2-4-Br-phenyl), --(CH.sub.2).sub.3O(2-NHC(.dbd.O)Me-4-phenyl), --(CH.sub.2).sub.3O(2-NHC(.dbd.O)Me-phenyl), --(CH.sub.2).sub.3NH(4-fluoro-phenyl), --(CH.sub.2).sub.3N(methyl)(4-fluoro-phenyl), --(CH.sub.2).sub.3CO.sub.2(ethyl), --(CH.sub.2).sub.3C(.dbd.O)N(methyl)(methoxy), --(CH.sub.2).sub.3C(.dbd.O)NH(4-fluoro-phenyl), --(CH.sub.2).sub.3NHC(.dbd.O)(phenyl), --(CH.sub.2).sub.2(NMeC(.dbd.O)(phenyl), --(CH.sub.2).sub.2NHC(.dbd.O)(2-fluoro-phenyl), --(CH.sub.2).sub.2NMeC(.dbd.O)(2-fluoro-phenyl), --(CH.sub.2).sub.2NHC(.dbd.O)(4-fluoro-phenyl), --(CH.sub.2).sub.2NMeC(.dbd.O)(4-fluoro-phenyl), --(CH.sub.2).sub.2NHC(.dbd.O)(2,4-difluoro-phenyl), --(CH.sub.2).sub.2NMeC(.dbd.O)(2,4-difluoro-phenyl), --(CH.sub.2).sub.3(3-indolyl), --(CH.sub.2).sub.3(1-methyl-3-indolyl), --(CH.sub.2).sub.3(1-indolyl), --(CH.sub.2).sub.3(1-indolinyl), --(CH.sub.2).sub.3(1-benzimidazolyl), --(CH.sub.2).sub.3(1H-1,2,3-benzotriazol-1-yl), --(CH.sub.2).sub.3(1H-1,2,3-benzotriazol-2-yl), --(CH.sub.2).sub.2(1H-1,2,3-benzotriazol-1-yl), --(CH.sub.2).sub.2(1H-1,2,3-benzotriazol-2-yl), --(CH.sub.2).sub.3(3,4
dihydro-1(2H)-quinolinyl), --(CH.sub.2).sub.2C(.dbd.O)(4-fluoro-phenyl), --(CH.sub.2).sub.2C(.dbd.O)NH(4-fluoro-phenyl), --CH.sub.2CH.sub.2(3-indolyl), --CH.sub.2CH.sub.2(1-phthalimidyl), --(CH.sub.2).sub.4C(.dbd.O)N(methyl)(methoxy), --(CH.sub.2).sub.4CO.sub.2(ethyl), --(CH.sub.2).sub.4C(.dbd.O)(phenyl), --(CH.sub.2).sub.3CH(phenyl).sub.2, --CH.sub.2CH.sub.2CH.dbd.C(phenyl).sub.2, --CH.sub.2CH.sub.2CH.dbd.CMe(4-F-phenyl), --(CH.sub.2).sub.3CH(4-fluoro-phenyl).sub.2, --CH.sub.2CH.sub.2CH.dbd.C(4-fluoro-phenyl).sub.2, --(CH.sub.2).sub.2(2,3-dihydro-1H-inden-2-yl), --(CH.sub.2).sub.3C(.dbd.O)(2-NH.sub.2-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NH.sub.2-5-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NH.sub.4-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NH.sub.2-3-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O((2-NH.sub.2-4-Cl-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NH.sub.2-4-OH-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NH.sub.2-4-Br-phenyl), --(CH.sub.2).sub.3(1H-indazol-3-yl), --(CH.sub.2).sub.3(5-F-1H-indazol-3-yl), --(CH.sub.2).sub.3(7-F-1H-indazol-3-yl), --(CH.sub.2).sub.3(6-Cl-1H-indazol-3-yl), --(CH.sub.2).sub.3(6-Br-1H-indazol-3-yl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHMe-phenyl), --(CH.sub.2).sub.3(1-benzothien-3-yl), --(CH.sub.2).sub.3(6-F-1H-indazol-1-yl), --(CH.sub.2).sub.3(5-F-1H-indazol-1-yl), --(CH.sub.2).sub.3(6-F-2,3-dihydro-1H-indol-1-yl), --(CH.sub.2).sub.3(5-F-2,3-dihydro-1H-indol-1-yl), --(CH.sub.2).sub.3(6-F-1H-indol-3-yl), --(CH.sub.2).sub.3(5-F-1H-indol-3-yl), --(CH.sub.2).sub.3(5-F-1H-indol-3-yl), --(CH.sub.2).sub.3(9H-purin-9-yl), --(CH.sub.2).sub.3(7H-purin-7-yl), --(CH.sub.2).sub.3(6-F-1H-indazol-3-yl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHSO.sub.2Me-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHC(.dbd.O)Me-4-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHC(.dbd.O)Me-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHCO.sub.2Et-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O) (2-NHC(.dbd.O)NHEt-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHCHO-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-OH-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-MeS-4-F-phenyl), --(CH.sub.2).sub.3C(.dbd.O)(2-NHSO.sub.2Me-4-F-phenyl), --(CH.sub.2).sub.2C(Me)CO.sub.2Me, --(CH.sub.2).sub.2C(Me)CH(OH)(4-F-phenyl).sub.2, --(CH.sub.2).sub.2C(Me)C(OH)(4-Cl-phenyl).sub.2, --(CH.sub.2).sub.2C(Me)C(.dbd.O)(4-F-phenyl), --(CH.sub.2).sub.2C(Me)C(.dbd.O)(2-MeO-4-F-phenyl), --(CH.sub.2).sub.2C(Me)C(.dbd.O)(3-Me-4-F-phenyl), --(CH.sub.2).sub.2C(Me)C(.dbd.O)(2-Me-phenyl), --(CH.sub.2).sub.2C(Me)C(.dbd.O)phenyl, ##STR00052## R.sup.7, R.sup.8, and R.sup.9, at each occurrence, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluromethyl, methoxy, ethoxy, isopropoxy, trifluoromethoxy, phenyl, benzyl, HC(.dbd.O)--, methylC(.dbd.O)--, ethylC(.dbd.O)--, propylC(.dbd.O)--, isopropylC(.dbd.O)--, n-butylC(.dbd.O)--, isobutylC(.dbd.O)--, secbutylC(.dbd.O)--, tertbutylC(.dbd.O)--, phenylC(.dbd.O)--, methylC(.dbd.O)NH--, ethylC(.dbd.O)NH--, propylC(.dbd.O)NH--, isopropylC(.dbd.O)NH--, n-butylC(.dbd.O)NH--, isobutylC(.dbd.O)NH--, secbutylC(.dbd.O)NH--, tertbutylC(.dbd.O)NH--, phenylC(.dbd.O)NH--, methylamino-, ethylamino-, propylamino-, isopropylamino-, n-butylamino-, isobutylamino-, secbutylamino-, tertbutylamino-, phenylamino-, p2 provided that two of substituents R.sup.7, R.sup.8, and R.sup.9, are independently selected from hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, nitro, trifluoromethyl, methoxy, ethoxy, isopropoxy, and trifluoromethoxy; k is 1 or 2; m is 1 or 2; and n is 1 or 2.
19. A compound of claim 18 of Formula (II-a) ##STR00053## wherein: b is a single bond, wherein the bridge hydrogens are in a cis position; R.s